Chloroquine and Hydroxychloroquine in Covid-19. eCollection 2023. Adipose-derived Exosomes Protect the Pulmonary Endothelial Barrier in Ventilator-Induced Lung Injury by Inhibiting the TRPV4/Ca2+ Signaling Pathway. TRPA1 distributes on C-fibers throughout the respiratory system (De Logu et al., 2016). Disclaimer. Clin. 382 (18), 17081720. S1 facilitates virus infection by binding to host receptors, and S2 regulates the membranes fusion to enable viral RNA entering into host cells for further replication. Am. doi:10.1007/s11596-015-1490-6, Jovanovi, S., Crawford, R. M., Ranki, H. J., and Jovanovi, A. As Towne et al., (2001) reported, AQP-5 expression significantly declined during pulmonary inflammation and edema, and TNF- decreased AQP5 mRNA and protein expression levels via TNFR1 and NF-B pathway (Towne et al., 2001). 50 (4), 113. Acta (Bba) - Biomembranes 1818 (7), 16821690. Cel Mol Biol 20 (5), 10281040. (2020). Mechanism of BK inducing pulmonary edema and potential drugs. Regulation of ENaC and CFTR Expression with K+ Channel Modulators and Effect on Fluid Absorption across Alveolar Epithelial Cells. However, among all current treatments mentioned above, little attention has been paid to the abnormal humoral metabolism and pulmonary edema, which is a key factor threatening patients lives. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Phytomedicine 85, 153282. doi:10.1016/j.phymed.2020.153282, Ma, Q., Pan, W., Li, R., Liu, B., Li, C., Xie, Y., et al. A., and Cook, D. I. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Cause of COVID-19 pulmonary edema. Moreover, it has been revealed that exosomes derived from human adipocyte can inhibit TRPV4-mediated calcium influx and thus protect mice against ventilator-induced lung injury (Yu et al., 2020). 288 (2), 192206. Chin. 12:664349. doi: 10.3389/fphar.2021.664349. (2020b). Mol. Thus, it could be a potential RdRp inhibitor for SARS-CoV-2 (Lung et al., 2020). doi:10.1161/01.RES.0000125623.56442.20, Nayler, W., and Dillon, J. (2020). The expression of AQP-5 is regulated by inflammatory cytokines, like TNF-, elevated in the plasma of critical COVID-19 patients (Hui and Zumla, 2019). Preprint. medRxiv. Coronavirus Disease 2019 Treatment A Review of Early and Emerging Options. However, clinical evidence showing that glucocorticoids can reduce pulmonary edema by regulating fluid absorption in alveolar and glucocorticoids is missing. It shows the vaccine is teaching your body's immune system how to protect itself from the disease. J. Physiology-Lung Cell Mol. Generalized Edema and Pseudothrombocytopenia After ChAdOx1 - PubMed J. Clin. doi:10.1152/ajplung.00244.2017, Looney, M. R., Sartori, C., Chakraborty, S., James, P. F., Lingrel, J. The first treatment for acute pulmonary edema is oxygen. doi:10.5114/pdia.2013.37040, Cui, M., Gosu, V., Basith, S., Hong, S., and Choi, S. (2016). The spike (S) protein of coronavirus, one of the surface glycoproteins, is divided into two functional units, S1 and S2. Acad. (2020). Fatal Systemic Capillary Leak Syndrome after SARS-CoV-2 Vaccination in Glucocorticoids were shown to have the ability of inducing de novo synthesis of ENaC (Chow et al., 1999; Otulakowski et al., 1999; Sayegh et al., 1999) and affecting ENaC regulatory pathway via serum and glucocorticoids-inducible kinase-1 (SGK-1) (Chen et al., 1999; de la Rosa et al., 1999; Itani et al., 2001; Zhang et al., 2007). doi:10.1152/ajplung.00085.2001, Ito, Y., Correll, K., Zemans, R. L., Leslie, C. C., Murphy, R. C., and Mason, R. J. eCollection 2021. doi:10.1073/pnas.160041997, Leroy, C., Priv, A., Bourret, J.-C., Berthiaume, Y., Ferraro, P., and Brochiero, E. (2006).
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